Description：

INK 128 (MLN0128) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.

Chemical Information：

Molecular Weight (MW)		309.33
Formula		C15H15N7O
CAS No.		1224844-38-5
Solubility (25°C) *	DMSO	62 mg/mL (200.43 mM)
	Water	Insoluble
	Alcohol	2 mg/mL (6.46 mM)

Biological Activity：

Targets IC50

GSK-3 68 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.2328 mL	16.1640 mL	32.3279 mL
5 mM	0.6466 mL	3.2328 mL	6.4656 mL
10 mM	0.3233 mL	1.6164 mL	3.2328 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL

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