Description：

A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.

Chemical Information：

Molecular Weight (MW)		359.25
Formula		C18H16Cl2N4
CAS No.		1982372-88-2
Solubility (25°C) *	DMSO	15 mg/mL (41.75 mM)
	Water	Insoluble
	Alcohol	12 mg/mL (33.4 mM)

Biological Activity：

Targets IC50

20S proteasome 0.6 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7836 mL	13.9179 mL	27.8358 mL
5 mM	0.5567 mL	2.7836 mL	5.5672 mL
10 mM	0.2784 mL	1.3918 mL	2.7836 mL
50 mM	0.0557 mL	0.2784 mL	0.5567 mL

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