Description：

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.

Chemical Information：

Molecular Weight (MW)		503.58
Formula		C28H21N7OS
CAS No.		945595-80-2
Solubility (25°C) *	DMSO	100 mg/mL (198.57 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Cdc2/cyclin B CDK2/cyclin A CDK2/cyclin E CDK5/p35 0.65 μM 0.7 μM 0.7 μM 0.16 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9858 mL	9.9289 mL	19.8578 mL
5 mM	0.3972 mL	1.9858 mL	3.9716 mL
10 mM	0.1986 mL	0.9929 mL	1.9858 mL
50 mM	0.0397 mL	0.1986 mL	0.3972 mL

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