Description：

AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.

Chemical Information：

Molecular Weight (MW)		383.4
Formula		C22H17N5O2
CAS No.		1002304-34-8
Solubility (25°C) *	DMSO	0.25 mg/mL (0.65 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

PANC1 MIAPaCa2 BxPC3 Capan2 cell lin 50 nM 40 nM 18 nM 12 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6082 mL	13.0412 mL	26.0824 mL
5 mM	0.5216 mL	2.6082 mL	5.2165 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL

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