Description：

GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.

Chemical Information：

Molecular Weight (MW)		498.64
Formula		C25H34N6O3S
CAS No.		873652-48-3
Solubility (25°C) *	DMSO	99 mg/mL (198.54 mM)
	Water	3 mg/mL (6.01 mM)
	Alcohol	99 mg/mL (198.54 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0055 mL	10.0273 mL	20.0545 mL
5 mM	0.4011 mL	2.0055 mL	4.0109 mL
10 mM	0.2005 mL	1.0027 mL	2.0055 mL
50 mM	0.0401 mL	0.2005 mL	0.4011 mL

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