Description：

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Chemical Information：

Molecular Weight (MW)		653.21
Formula		C32H48N4O8•HCl
CAS No.		467214-21-7
Solubility (25°C) *	DMSO	131 mg/mL (200.54 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

DHFR TS GARFT 7.2 nM (Ki) 1.3 nM (Ki) 65 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.5309 mL	7.6545 mL	15.3090 mL
5 mM	0.3062 mL	1.5309 mL	3.0618 mL
10 mM	0.1531 mL	0.7655 mL	1.5309 mL
50 mM	0.0306 mL	0.1531 mL	0.3062 mL

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