Description：

Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		401.84
Formula		C21H20ClNO5
CAS No.		146426-40-6
Solubility (25°C) *	DMSO	15 mg/mL (37.32 mM)
	Water	Insoluble
	Alcohol	8 mg/mL (19.9 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4886 mL	12.4428 mL	24.8855 mL
5 mM	0.4977 mL	2.4886 mL	4.9771 mL
10 mM	0.2489 mL	1.2443 mL	2.4886 mL
50 mM	0.0498 mL	0.2489 mL	0.4977 mL

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