Description：

Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.

Chemical Information：

Molecular Weight (MW)		441.47
Formula		C19H22F3N5O2S
CAS No.		1217486-61-7
Solubility (25°C) *	DMSO	88 mg/mL (199.33 mM)
	Water	Insoluble
	Alcohol	2 mg/mL (4.53 mM)

Biological Activity：

Targets IC50

IR Met IGF-1R TrkB TrkA 1.7 nM 5.6 nM 1.8 nM 4.1 nM 7.4 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2652 mL	11.3258 mL	22.6516 mL
5 mM	0.4530 mL	2.2652 mL	4.5303 mL
10 mM	0.2265 mL	1.1326 mL	2.2652 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL

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