Description：

Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2.

Chemical Information：

Molecular Weight (MW)		560.64
Formula		C31H34F2N6O2
CAS No.		1108743-60-7
Solubility (25°C) *	DMSO	100 mg/mL (178.36 mM)
	Water	Insoluble
	Alcohol	75 mg/mL (133.77 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7837 mL	8.9184 mL	17.8368 mL
5 mM	0.3567 mL	1.7837 mL	3.5674 mL
10 mM	0.1784 mL	0.8918 mL	1.7837 mL
50 mM	0.0357 mL	0.1784 mL	0.3567 mL

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