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Almorexant HCl

Almorexant HCl

Catalog Number: CC2316 Rank: comment rank 5

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Description:

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Chemical Information:

Molecular Weight (MW) 549.02
Formula

 

C29H32ClF3N2O3

 

CAS No. 913358-93-7
Solubility (25°C) * DMSO 72 mg/mL (131.14 mM)
Water Insoluble
Alcohol 51 mg/mL (92.89 mM)


Biological Activity:

Targets
IC50
CDK6/cyclin D2 CDK4/cyclin D1
16 nM 11 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.8214 mL 9.1071 mL 18.2143 mL
5 mM 0.3643 mL 1.8214 mL 3.6429 mL
10 mM 0.1821 mL 0.9107 mL 1.8214 mL
50 mM 0.0364 mL 0.1821 mL 0.3643 mL


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