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Dovitinib (TKI258) Lactate

Dovitinib (TKI258) Lactate

Catalog Number: CC7921 Rank: comment rank 5

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$ 207.00
$ 592.00
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Description:

Dovitinib (TKI258) Lactate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.

Chemical Information:

Molecular Weight (MW) 482.51
Formula

 

C24H27FN6O4

 

CAS No. 915769-50-5
Solubility (25°C) * DMSO 100 mg/mL (207.24 mM)
Water 66 mg/mL warmed (136.78 mM)
Alcohol 1 mg/mL warmed (2.07 mM)


Biological Activity:

Targets
IC50
norepinephrine (
5 nM (Ki)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.0725 mL 10.3625 mL 20.7250 mL
5 mM 0.4145 mL 2.0725 mL 4.1450 mL
10 mM 0.2072 mL 1.0362 mL 2.0725 mL
50 mM 0.0414 mL 0.2072 mL 0.4145 mL


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