Description：

Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.

Chemical Information：

Molecular Weight (MW)		392.43
Formula		C21H21FN6O
CAS No.		405169-16-6
Solubility (25°C) *	DMSO	30 mg/mL (76.44 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5482 mL	12.7411 mL	25.4823 mL
5 mM	0.5096 mL	2.5482 mL	5.0965 mL
10 mM	0.2548 mL	1.2741 mL	2.5482 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL

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