Description：

Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells.

Chemical Information：

Molecular Weight (MW)		411.62
Formula		C27H41NO2
CAS No.		4449-51-8
Solubility (25°C) *	DMSO	Insoluble
	Water
	Alcohol	2 mg/mL warmed (4.85 mM)

Biological Activity：

Targets IC50

Cathepsin L2 Cathepsin L Cathepsin S Cathepsin B Cathepsin K 6.7 (pIC50) 7.9 (pIC50) 6.0 (pIC50) 5.2 (pIC50) 5.5 (pIC50)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4294 mL	12.1471 mL	24.2943 mL
5 mM	0.4859 mL	2.4294 mL	4.8589 mL
10 mM	0.2429 mL	1.2147 mL	2.4294 mL
50 mM	0.0486 mL	0.2429 mL	0.4859 mL

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