Search  
Your Position: Home > Protein Tyrosine Kinase > PDGFR inhibitor > Crenolanib (CP-868596)
All Categories
Crenolanib (CP-868596)

Crenolanib (CP-868596)

Catalog Number: CC2886 Rank: comment rank 5

Size Price Qty
$ 118.00
$ 224.00
$ 679.00
Total:
    
ChecmCatch Tel: 021-65878381 QQ Online
Email: kelvinyeng@hotmail.com    info@chemcatch.cn

Goods Info

Releate

Other

Description:

Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.

Chemical Information:

Molecular Weight (MW) 443.54
Formula

 

C26H29N5O2

 

CAS No. 670220-88-9
Solubility (25°C) * DMSO 88 mg/mL warmed (198.4 mM)
Water Insoluble
Alcohol 7 mg/mL (15.78 mM)


Biological Activity:

Targets
IC50
Bcl-xL Mcl-1 Bcl-2
0.48 μM (Ki) 0.18 μM (Ki) [1 0.32 μM (Ki)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2546 mL 11.2729 mL 22.5459 mL
5 mM 0.4509 mL 2.2546 mL 4.5092 mL
10 mM 0.2255 mL 1.1273 mL 2.2546 mL
50 mM 0.0451 mL 0.2255 mL 0.4509 mL


Bought notes(bought amounts latest0)

No one bought this product
Total 0 records, divided into1 pages. First Prev Next Last
Chem Catch products are for research use only. Not for human use. We do not sell to patients.

沪ICP备16042327号-2