Description：

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.

Chemical Information：

Molecular Weight (MW)		417.5
Formula		C24H27N5O2
CAS No.		343787-29-1
Solubility (25°C) *	DMSO	28 mg/mL warmed (67.06 mM)
	Water	Insoluble
	Alcohol	4 mg/mL (9.58 mM)

Biological Activity：

Targets IC50

H-ras K-ras-4B N-ras 1.9 nM 5.2 nM 2.8 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3952 mL	11.9760 mL	23.9521 mL
5 mM	0.4790 mL	2.3952 mL	4.7904 mL
10 mM	0.2395 mL	1.1976 mL	2.3952 mL
50 mM	0.0479 mL	0.2395 mL	0.4790 mL

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