Description：

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

Chemical Information：

Molecular Weight (MW)		485.94
Formula		C24H25ClFN5O3
CAS No.		439081-18-2
Solubility (25°C) *	DMSO	97 mg/mL (199.61 mM)
	Water	Insoluble
	Alcohol	15 mg/mL (30.86 mM)

Biological Activity：

Targets IC50

Met 10 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0579 mL	10.2893 mL	20.5787 mL
5 mM	0.4116 mL	2.0579 mL	4.1157 mL
10 mM	0.2058 mL	1.0289 mL	2.0579 mL
50 mM	0.0412 mL	0.2058 mL	0.4116 mL

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