Description：

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

Chemical Information：

Molecular Weight (MW)		702.68
Formula		C29H41F3N8O9
CAS No.		199807-35-7
Solubility (25°C) *	DMSO	100 mg/mL (142.31 mM)
	Water	8 mg/mL (11.38 mM)
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Hep G2 Hep 3B HuH7 PLC/PRF/5 60 nM (GI50) [1 26 nM (GI50) 9 nM (GI50) 13 nM (GI50)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.4231 mL	7.1156 mL	14.2312 mL
5 mM	0.2846 mL	1.4231 mL	2.8462 mL
10 mM	0.1423 mL	0.7116 mL	1.4231 mL
50 mM	0.0285 mL	0.1423 mL	0.2846 mL

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