Description：

Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with K_d of <1 nM in a cell-free assay, less potent to XIAP. Phase 2.

Chemical Information：

Molecular Weight (MW)		806.94
Formula		C42H56F2N8O6
CAS No.		1260251-31-7
Solubility (25°C) *	DMSO	100 mg/mL (123.92 mM)
	Water	Insoluble
	Alcohol	55 mg/mL (68.15 mM)

Biological Activity：

Targets IC50

KSP (P388 cells) KSP (SKOV3 cell KSP (MV522 cell KSP (Colo205 ce KSP (MX1 cells) 14.4 nM 0.2 nM 1.7 nM 0.07 nM 0.06 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.2392 mL	6.1962 mL	12.3925 mL
5 mM	0.2478 mL	1.2392 mL	2.4785 mL
10 mM	0.1239 mL	0.6196 mL	1.2392 mL
50 mM	0.0248 mL	0.1239 mL	0.2478 mL

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