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Description:
Acalabrutinib(ACP-196) is a selective second-generation Bruton\'s tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
Chemical Information:
Molecular Weight (MW) 465.51 Formula
C26H23N7O2
CAS No. 1420477-60-6 Solubility (25°C) * DMSO 93 mg/mL (199.78 mM) Water Insoluble Alcohol 93 mg/mL (199.78 mM)
Biological Activity:
Targets IC50
VEGFR2 PDGFRβ B-Raf Raf-1 90 nM 57 nM 22 nM 6 nM
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.1482 mL 10.7409 mL 21.4818 mL 5 mM 0.4296 mL 2.1482 mL 4.2964 mL 10 mM 0.2148 mL 1.0741 mL 2.1482 mL 50 mM 0.0430 mL 0.2148 mL 0.4296 mL
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