Search  
Your Position: Home > Angiogenesis > BTK inhibitor > Acalabrutinib (ACP-196)
All Categories
Acalabrutinib (ACP-196)

Acalabrutinib (ACP-196)

Catalog Number: CC8272 Rank: comment rank 5

Size Price Qty
$ 277.00
$ 697.00
$ 74.00
Total:
    
ChecmCatch Tel: 021-65878381 QQ Online
Email: kelvinyeng@hotmail.com    info@chemcatch.cn

Goods Info

Releate

Other

Description:

Acalabrutinib(ACP-196) is a selective second-generation Bruton\'s tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.

Chemical Information:

Molecular Weight (MW) 465.51
Formula

 

C26H23N7O2

 

CAS No. 1420477-60-6
Solubility (25°C) * DMSO 93 mg/mL (199.78 mM)
Water Insoluble
Alcohol 93 mg/mL (199.78 mM)


Biological Activity:

Targets
IC50
VEGFR2 PDGFRβ B-Raf Raf-1
90 nM 57 nM 22 nM 6 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1482 mL 10.7409 mL 21.4818 mL
5 mM 0.4296 mL 2.1482 mL 4.2964 mL
10 mM 0.2148 mL 1.0741 mL 2.1482 mL
50 mM 0.0430 mL 0.2148 mL 0.4296 mL


Bought notes(bought amounts latest0)

No one bought this product
Total 0 records, divided into1 pages. First Prev Next Last
Chem Catch products are for research use only. Not for human use. We do not sell to patients.

沪ICP备16042327号-2