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PDGFR inhibitor 1

PDGFR inhibitor 1

Catalog Number: CC8877 Rank: comment rank 5

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Description:

PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of KIT and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.

Chemical Information:

Molecular Weight (MW) 489.47
Formula

 

C26H21F2N5O3

 

CAS No. 1225278-16-9
Solubility (25°C) * DMSO 97 mg/mL (198.17 mM)
Water Insoluble
Alcohol 9 mg/mL (18.39 mM)


Preparing Stock Solutions

Concentration Volume(DMSO)Mass1 mg5 mg10 mg
1 mM2.0430 mL10.2151 mL20.4303 mL
5 mM0.4086mL2.0430 mL4.0861 mL
10 mM0.2043 mL1.0215 mL2.0430 mL
50 mM0.0409 mL0.2043 mL0.4086 mL


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