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(+)-Bicuculline

(+)-Bicuculline

Catalog Number: CC7227 Rank: comment rank 5

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Description:

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

Chemical Information:

Molecular Weight (MW) 367.35
Formula

 

C20H17NO6

 

CAS No. 485-49-4
Solubility (25°C) * DMSO 21 mg/mL warmed (57.16 mM)
Water Insoluble
Alcohol Insoluble


Biological Activity:

Targets
IC50
SIRT1
38 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.7222 mL 13.6110 mL 27.2220 mL
5 mM 0.5444 mL 2.7222 mL 5.4444 mL
10 mM 0.2722 mL 1.3611 mL 2.7222 mL
50 mM 0.0544 mL 0.2722 mL 0.5444 mL


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