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WYE-687

WYE-687

Catalog Number: CC2824 Rank: comment rank 5

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$ 189.00
$ 259.00
$ 679.00
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Description:

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).

Chemical Information:

Molecular Weight (MW) 528.61
Formula

 

C28H32N8O3

 

CAS No. 1062161-90-3
Solubility (25°C) * DMSO 0.5 mg/mL (0.94 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.8918 mL 9.4588 mL 18.9175 mL
5 mM 0.3784 mL 1.8918 mL 3.7835 mL
10 mM 0.1892 mL 0.9459 mL 1.8918 mL
50 mM 0.0378 mL 0.1892 mL 0.3784 mL


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