Description：

VX-809 (Lumacaftor) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.

Chemical Information：

Molecular Weight (MW)		452.41
Formula		C24H18F2N2O5
CAS No.		936727-05-8
Solubility (25°C) *	DMSO	90 mg/mL (198.93 mM)
	Water	Insoluble
	Alcohol	6 mg/mL (13.26 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2104 mL	11.0519 mL	22.1038 mL
5 mM	0.4421 mL	2.2104 mL	4.4208 mL
10 mM	0.2210 mL	1.1052 mL	2.2104 mL
50 mM	0.0442 mL	0.2210 mL	0.4421 mL

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