Description：

Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM.

Chemical Information：

Molecular Weight (MW)		475.35
Formula		C22H24BrFN4O2
CAS No.		443913-73-3
Solubility (25°C) *	DMSO	4 mg/mL (8.41 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1037 mL	10.5186 mL	21.0371 mL
5 mM	0.4207 mL	2.1037 mL	4.2074 mL
10 mM	0.2104 mL	1.0519 mL	2.1037 mL
50 mM	0.0421 mL	0.2104 mL	0.4207 mL

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