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Trametinib (GSK1120212)

Trametinib (GSK1120212)

Catalog Number: CC2829 Rank: comment rank 5

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Description:

Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

Chemical Information:

Molecular Weight (MW) 615.39
Formula

 

C26H23FIN5O4

 

CAS No. 871700-17-3
Solubility (25°C) * DMSO 22 mg/mL warmed (35.74 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.6250 mL 8.1249 mL 16.2499 mL
5 mM 0.3250 mL 1.6250 mL 3.2500 mL
10 mM 0.1625 mL 0.8125 mL 1.6250 mL
50 mM 0.0325 mL 0.1625 mL 0.3250 mL


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