Description：

Tivozanib (AV-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.

Chemical Information：

Molecular Weight (MW)		454.86
Formula		C22H19ClN4O5
CAS No.		475108-18-0
Solubility (25°C) *	DMSO	20 mg/mL (43.96 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1985 mL	10.9924 mL	21.9848 mL
5 mM	0.4397 mL	2.1985 mL	4.3970 mL
10 mM	0.2198 mL	1.0992 mL	2.1985 mL
50 mM	0.0440 mL	0.2198 mL	0.4397 mL

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