Description：

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

Chemical Information：

Molecular Weight (MW)		484.9
Formula		C21H23F3N6O2.HCl
CAS No.		899805-25-5 (free base)
Solubility (25°C) *	DMSO	89 mg/mL warmed (183.54 mM)
	Water	4 mg/mL warmed (8.24 mM)
	Alcohol	89 mg/mL warmed (183.54 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0623 mL	10.3114 mL	20.6228 mL
5 mM	0.4125 mL	2.0623 mL	4.1246 mL
10 mM	0.2062 mL	1.0311 mL	2.0623 mL
50 mM	0.0412 mL	0.2062 mL	0.4125 mL

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