Description：

Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.

Chemical Information：

Molecular Weight (MW)		562.7
Formula		C31H42N6O4
CAS No.		387867-13-2
Solubility (25°C) *	DMSO	5 mg/mL (8.88 mM)
	Water	Insoluble
	Alcohol	6 mg/mL (10.66 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7771 mL	8.8857 mL	17.7715 mL
5 mM	0.3554 mL	1.7771 mL	3.5543 mL
10 mM	0.1777 mL	0.8886 mL	1.7771 mL
50 mM	0.0355 mL	0.1777 mL	0.3554 mL

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