Description：

Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.

Chemical Information：

Molecular Weight (MW)		485.5
Formula		C26H26F3N3O3
CAS No.		956697-53-3
Solubility (25°C) *	DMSO	97 mg/mL (199.79 mM)
	Water	Insoluble
	Alcohol	97 mg/mL warmed (199.79 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0597 mL	10.2987 mL	20.5973 mL
5 mM	0.4119 mL	2.0597 mL	4.1195 mL
10 mM	0.2060 mL	1.0299 mL	2.0597 mL
50 mM	0.0412 mL	0.2060 mL	0.4119 mL

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