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SGI-1776 free base

SGI-1776 free base

Catalog Number: CC2354 Rank: comment rank 5

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Description:

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Chemical Information:

Molecular Weight (MW) 405.42
Formula

 

C20H22F3N5O

 

CAS No. 1025065-69-3
Solubility (25°C) * DMSO 81 mg/mL (199.79 mM)
Water Insoluble
Alcohol 81 mg/mL (199.79 mM)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.4666 mL 12.3329 mL 24.6658 mL
5 mM 0.4933 mL 2.4666 mL 4.9332 mL
10 mM 0.2467 mL 1.2333 mL 2.4666 mL
50 mM 0.0493 mL 0.2467 mL 0.4933 mL


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