Description：

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.

Chemical Information：

Molecular Weight (MW)		452.55
Formula		C24H32N6O3
CAS No.		1124329-14-1
Solubility (25°C) *	DMSO	28 mg/mL (61.87 mM)
	Water	Insoluble
	Alcohol	91 mg/mL (201.08 mM)

Biological Activity：

Targets IC50

Aurora C Aurora B Aurora A 120 nM 135 nM 27 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2097 mL	11.0485 mL	22.0970 mL
5 mM	0.4419 mL	2.2097 mL	4.4194 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL

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