Description：

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

Chemical Information：

Molecular Weight (MW)		322.3
Formula		C16H11FN6O
CAS No.		895158-95-9
Solubility (25°C) *	DMSO	28 mg/mL (86.87 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.1027 mL	15.5135 mL	31.0270 mL
5 mM	0.6205 mL	3.1027 mL	6.2054 mL
10 mM	0.3103 mL	1.5513 mL	3.1027 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL

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