Description：

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Chemical Information：

Molecular Weight (MW)		520.88
Formula		C20H17ClF4N4O4S
CAS No.		1146699-66-2
Solubility (25°C) *	DMSO	104 mg/mL (199.66 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9198 mL	9.5991 mL	19.1983 mL
5 mM	0.3840 mL	1.9198 mL	3.8397 mL
10 mM	0.1920 mL	0.9599 mL	1.9198 mL
50 mM	0.0384 mL	0.1920 mL	0.3840 mL

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