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Avadomide(CC-122)

Avadomide(CC-122)

Catalog Number: CC8048 Rank: comment rank 5

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Description:

Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.

Chemical Information:

Molecular Weight (MW) 286.29
Formula

 

C14H14N4O3

 

CAS No. 1015474-32-4
Solubility (25°C) * DMSO 57 mg/mL (199.09 mM)
Water Insoluble
Alcohol 1 mg/mL (3.49 mM)


Biological Activity:

Targets
IC50
HDAC8 HDAC6 HDAC3
1.46 μM 2.47 μM 16.9 μM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.4930 mL 17.4648 mL 34.9296 mL
5 mM 0.6986 mL 3.4930 mL 6.9859 mL
10 mM 0.3493 mL 1.7465 mL 3.4930 mL
50 mM 0.0699 mL 0.3493 mL 0.6986 mL


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