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RO5126766 (CH5126766)

RO5126766 (CH5126766)

Catalog Number: CC7326 Rank: comment rank 5

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Description:

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

Chemical Information:

Molecular Weight (MW) 471.46
Formula

 

C21H18FN5O5S

 

CAS No. 946128-88-7
Solubility (25°C) * DMSO 94 mg/mL (199.38 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1211 mL 10.6054 mL 21.2107 mL
5 mM 0.4242 mL 2.1211 mL 4.2421 mL
10 mM 0.2121 mL 1.0605 mL 2.1211 mL
50 mM 0.0424 mL 0.2121 mL 0.4242 mL


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