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Ricolinostat (ACY-1215)

Ricolinostat (ACY-1215)

Catalog Number: CC8157 Rank: comment rank 5

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Description:

Ricolinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Phase 2.

Chemical Information:

Molecular Weight (MW) 433.5
Formula

 

C24H27N5O3

 

CAS No. 1316214-52-4
Solubility (25°C) * DMSO 86 mg/mL (198.38 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.3068 mL 11.5340 mL 23.0681 mL
5 mM 0.4614 mL 2.3068 mL 4.6136 mL
10 mM 0.2307 mL 1.1534 mL 2.3068 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL


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