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RAF265 (CHIR-265)

RAF265 (CHIR-265)

Catalog Number: CC2317 Rank: comment rank 5

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Description:

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. Phase 2.

Chemical Information:

Molecular Weight (MW) 518.41
Formula

 

C24H16F6N6O

 

CAS No. 927880-90-8
Solubility (25°C) * DMSO 100 mg/mL (192.89 mM)
Water Insoluble
Alcohol 33 mg/mL (63.65 mM)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.9290 mL 9.6449 mL 19.2898 mL
5 mM 0.3858 mL 1.9290 mL 3.8580 mL
10 mM 0.1929 mL 0.9645 mL 1.9290 mL
50 mM 0.0386 mL 0.1929 mL 0.3858 mL


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