Description：

R428 (BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).

Chemical Information：

Molecular Weight (MW)		506.64
Formula		C30H34N8
CAS No.		1037624-75-1
Solubility (25°C) *	DMSO	6 mg/mL warmed (11.84 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9738 mL	9.8689 mL	19.7379 mL
5 mM	0.3948 mL	1.9738 mL	3.9476 mL
10 mM	0.1974 mL	0.9869 mL	1.9738 mL
50 mM	0.0395 mL	0.1974 mL	0.3948 mL

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