Description：

Poziotinib (HM781-36B) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Phase 2.

Chemical Information：

Molecular Weight (MW)		491.34
Formula		C23H21Cl2FN4O3
CAS No.		1092364-38-9
Solubility (25°C) *	DMSO	98 mg/mL (199.45 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0353 mL	10.1763 mL	20.3525 mL
5 mM	0.4071 mL	2.0353 mL	4.0705 mL
10 mM	0.2035 mL	1.0176 mL	2.0353 mL
50 mM	0.0407 mL	0.2035 mL	0.4071 mL

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