Description：

PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>10⁵-fold differential relative to the Ki on PIMs).

Chemical Information：

Molecular Weight (MW)		476.92
Formula		C24H23F3N4O.HCl
CAS No.		1210608-43-7(free base)
Solubility (25°C) *	DMSO	88 mg/mL (184.51 mM)
	Water	Insoluble
	Alcohol	88 mg/mL (184.51 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0968 mL	10.4839 mL	20.9679 mL
5 mM	0.4194 mL	2.0968 mL	4.1936 mL
10 mM	0.2097 mL	1.0484 mL	2.0968 mL
50 mM	0.0419 mL	0.2097 mL	0.4194 mL

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