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PF-562271 HCl

PF-562271 HCl

Catalog Number: CC7513 Rank: comment rank 5

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Description:

PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.

Chemical Information:

Molecular Weight (MW) 543.95
Formula

 

C21H21ClF3N7O3S

 

CAS No. 939791-41-0
Solubility (25°C) * DMSO 100 mg/mL (183.84 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.8384 mL 9.1920 mL 18.3840 mL
5 mM 0.3677 mL 1.8384 mL 3.6768 mL
10 mM 0.1838 mL 0.9192 mL 1.8384 mL
50 mM 0.0368 mL 0.1838 mL 0.3677 mL


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