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PF-5274857

PF-5274857

Catalog Number: CC2933 Rank: comment rank 5

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$ 189.00
$ 329.00
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Description:

PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

Chemical Information:

Molecular Weight (MW) 436.96
Formula

 

C20H25ClN4O3S

 

CAS No. 1373615-35-0
Solubility (25°C) * DMSO 93 mg/mL (212.83 mM)
Water 93 mg/mL (212.83 mM)
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2885 mL 11.4427 mL 22.8854 mL
5 mM 0.4577 mL 2.2885 mL 4.5771 mL
10 mM 0.2289 mL 1.1443 mL 2.2885 mL
50 mM 0.0458 mL 0.2289 mL 0.4577 mL


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