Description：

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.

Chemical Information：

Molecular Weight (MW)		581.5
Formula		C30H30Cl2N4O4
CAS No.		890090-75-2
Solubility (25°C) *	DMSO	100 mg/mL (171.96 mM)
	Water	Insoluble
	Alcohol	30 mg/mL (51.59 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7197 mL	8.5985 mL	17.1969 mL
5 mM	0.3439 mL	1.7197 mL	3.4394 mL
10 mM	0.1720 mL	0.8598 mL	1.7197 mL
50 mM	0.0344 mL	0.1720 mL	0.3439 mL

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