Description：

NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).

Chemical Information：

Molecular Weight (MW)		395.42
Formula		C20H24F3N3O2
CAS No.		1262417-51-5
Solubility (25°C) *	DMSO	24 mg/mL warmed (60.69 mM)
	Water	Insoluble
	Alcohol	5 mg/mL warmed (12.64 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5290 mL	12.6448 mL	25.2896 mL
5 mM	0.5058 mL	2.5290 mL	5.0579 mL
10 mM	0.2529 mL	1.2645 mL	2.5290 mL
50 mM	0.0506 mL	0.2529 mL	0.5058 mL

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