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Marinopyrrole A (Maritoclax)

Marinopyrrole A (Maritoclax)

Catalog Number: CC7282 Rank: comment rank 5

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Description:

Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.

Chemical Information:

Molecular Weight (MW) 510.15
Formula

 

C22H12Cl4N2O4

 

CAS No. 1227962-62-0
Solubility (25°C) * DMSO 100 mg/mL (196.02 mM)
Water Insoluble
Alcohol 45 mg/mL (88.2 mM)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.9602 mL 9.8010 mL 19.6021 mL
5 mM 0.3920 mL 1.9602 mL 3.9204 mL
10 mM 0.1960 mL 0.9801 mL 1.9602 mL
50 mM 0.0392 mL 0.1960 mL 0.3920 mL


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