Description：

LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.

Chemical Information：

Molecular Weight (MW)		320.36
Formula		C15H14F2N4S
CAS No.		1194044-20-6
Solubility (25°C) *	DMSO	16 mg/mL (49.94 mM)
	Water	Insoluble
	Alcohol	64 mg/mL (199.77 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.1215 mL	15.6074 mL	31.2149 mL
5 mM	0.6243 mL	3.1215 mL	6.2430 mL
10 mM	0.3121 mL	1.5607 mL	3.1215 mL
50 mM	0.0624 mL	0.3121 mL	0.6243 mL

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