Description：

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with K_i of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. Phase 1.

Chemical Information：

Molecular Weight (MW)		406.41
Formula		C21H19FN6O2
CAS No.		1454846-35-5
Solubility (25°C) *	DMSO	81 mg/mL warmed (199.3 mM)
	Water	Insoluble
	Alcohol	30 mg/mL warmed (73.81 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4606 mL	12.3028 mL	24.6057 mL
5 mM	0.4921 mL	2.4606 mL	4.9211 mL
10 mM	0.2461 mL	1.2303 mL	2.4606 mL
50 mM	0.0492 mL	0.2461 mL	0.4921 mL

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