Description：

KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.

Chemical Information：

Molecular Weight (MW)		332.4
Formula		C20H20N4O
CAS No.		1000669-72-6
Solubility (25°C) *	DMSO	67 mg/mL (201.56 mM)
	Water	Insoluble
	Alcohol	67 mg/mL (201.56 mM)

Biological Activity：

Targets IC50

MT1-MMP

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.0084 mL	15.0421 mL	30.0842 mL
5 mM	0.6017 mL	3.0084 mL	6.0168 mL
10 mM	0.3008 mL	1.5042 mL	3.0084 mL
50 mM	0.0602 mL	0.3008 mL	0.6017 mL

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