Description：

Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.

Chemical Information：

Molecular Weight (MW)		392.49
Formula		C24H28N2O3
CAS No.		873054-44-5
Solubility (25°C) *	DMSO	78 mg/mL (198.73 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

TGM2 JAK1 EGFR 10 nM 4.4（pIC50） 5.6（pIC50）

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5478 mL	12.7392 mL	25.4784 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL

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