Description：

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

Chemical Information：

Molecular Weight (MW)		313.86
Formula		C20H23N.HCl
CAS No.		549-18-8
Solubility (25°C) *	DMSO	63 mg/mL (200.72 mM)
	Water	15 mg/mL (47.79 mM)
	Alcohol	63 mg/mL (200.72 mM)

Biological Activity：

Targets IC50

EGFR E746_A750 EGFR L858R/T790 EGFR L858R EGFR E746_A750/ 2 nM 5 nM 2 nM 14 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.1861 mL	15.9307 mL	31.8613 mL
5 mM	0.6372 mL	3.1861 mL	6.3723 mL
10 mM	0.3186 mL	1.5931 mL	3.1861 mL
50 mM	0.0637 mL	0.3186 mL	0.6372 mL

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